Formic Acid → 3-(2-Thienyl)piperazine-2,5-dione
반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]([NH:11][C:12](=[O:22])[CH2:13][NH:14][C:15](OC(C)(C)C)=[O:16])C(OC)=O.C(O)=O>C1(C)C=CC=CC=1.C(O)CCC>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]1[NH:11][C:12](=[O:22])[CH2:13][NH:14][C:15]1=[O:16]참가 물질
5
실험 절차
A mixture of 6.4 g of methyl 2-thienyl-N-(tert.-butoxycarbonylaminoacetyl)aminoacetate and 200 ml of formic acid is stirred at room temperature for 15 h. The volatile fractions are stripped off in vacuo, and the residue is heated to boiling in a mixture of 80 ml of toluene and 300 ml of butanol under reflux for 3 h. The solvents are then removed in a rotary evaporator, and the residue is recrystallized from methanol.
후처리
- temperaturethe residue is heated
- temperatureunder reflux for 3 h
- customThe solvents are then removed in a rotary evaporator
- customthe residue is recrystallized from methanol
출처 및 근거
- ORD 기록
- ord-6193f14686304ddeb58d632a033544b9
- 출처 데이터셋
- uspto-grants-1991_01
- 특허 번호
- US04987134
반응 노트
불러오는 중…