Hydrochloric Acid → 5,6-dimethoxy-2,3-dihydro-1H-isoindole hydrochloride
반응식
C([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([O:19][CH3:20])=[C:13]([O:17][CH3:18])[CH:14]=2)[CH2:9]1)C1C=CC=CC=1.[ClH:21]>CO.[C].[Pd]>[ClH:21].[CH3:18][O:17][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][C:12]=1[O:19][CH3:20])[CH2:9][NH:8][CH2:16]2참가 물질
5
실험 절차
1.00 g (3.72 mmol) of 2-benzyl-5,6-dimethoxyisoindoline was dissolved in 50 ml of methanol at 40° C., and then 1.24 g (7.44 mmol) of 6N hydrochloric acid and 70 mg of 10% palladium carbon were added thereto. Under a hydrogen gas stream, catalytic reduction was conducted at the same temperature. The solvent was distilled off under reduced pressure, and the crystalline residue was washed with acetone to obtain 758 mg (yield: 94.3%) of the above identified compound as colorless prism crystals.
후처리
- distillationThe solvent was distilled off under reduced pressure
- washthe crystalline residue was washed with acetone
- customto obtain 758 mg (yield: 94.3%) of the
출처 및 근거
- ORD 기록
- ord-d9811e2d818d4c0bb51f48c7003af726
- 출처 데이터셋
- uspto-grants-1991_01
- 특허 번호
- US04987235
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