Acetic Anhydride → 5,6-Diacetoxy-2-acetylindoline

HRID 704461노트

반응식

HRID 704461 반응식
Br.[OH:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[OH:12])[CH2:8][NH:7][CH2:6]2.C(O[C:17](=[O:19])[CH3:18])(=O)C>N1C=CC=CC=1>[C:3]([O:12][C:11]1[CH:10]=[C:9]2[C:8](=[CH:4][C:3]=1[O:2][C:11](=[O:12])[CH3:10])[NH:7][CH:6]([C:17](=[O:19])[CH3:18])[CH2:5]2)(=[O:2])[CH3:4]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 200743492,3-dihydro-1H-isoindole-5,6-diol hydrobromide

생성물 1

HCID 200743545,6-Diacetoxy-2-acetylindoline수율 89%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

500 mg (2.15 mmol) of 5,6-dihydroxyisoindoline hydrobromide was dissolved in 2.5 ml of pyridine, and 2.5 ml of acetic anhydride was added thereto at room temperature. The mixture was stirred at the same temperature for 30 minutes, and then excess pyridine and acetic anhydride were distilled off under reduced pressure. Ethyl acetate was added to the residue, and insoluble matters were filtered off. The filtrate was concentrated under reduced pressure, and the crystalline residue was washed with ethyl ether to obtain 532 mg (yield: 89.0%) of the above identified compound.

후처리

  1. customat room temperature
  2. distillationexcess pyridine and acetic anhydride were distilled off under reduced pressure
  3. additionEthyl acetate was added to the residue, and insoluble matters
  4. filtrationwere filtered off
  5. concentrationThe filtrate was concentrated under reduced pressure
  6. washthe crystalline residue was washed with ethyl ether
  7. customto obtain 532 mg (yield: 89.0%) of the

출처 및 근거

ORD 기록
ord-1ad1245ddf7144329cf86870edd6fbe9
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04987235

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