Benzylamine → 1-methyl-5-phenyl-3-{(phenylmethyl)-amino}-1H-1,5-benzodiazepine-2,4(3H, 5H)-dione

HRID 704557노트

반응식

HRID 704557 반응식
Br[CH:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[N:4]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:3]1=[O:21].[CH2:22]([NH2:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>O>[CH3:10][N:7]1[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[N:4]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:3](=[O:21])[CH:2]([NH:29][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:8]1=[O:9]

참가 물질

4

반응물 2

HCID 7504BenzylamineHCID 146976583-bromo-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4-(3H, 5H)-dione

생성물 1

HCID 146976591-methyl-5-phenyl-3-{(phenylmethyl)-amino}-1H-1,5-benzodiazepine-2,4(3H, 5H)-dione

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

A mixture of 50 mg of the product of Step B and 2 ml of benzylamine was heated at 100° C. for 3 hours and the reaction medium was poured into water. The product obtained was separated, washed, and dried in the presence of phosphoric anhydride to obtain 50 mg of the sought product.

후처리

  1. customThe product obtained
  2. customwas separated
  3. washwashed
  4. dry with materialdried in the presence of phosphoric anhydride

출처 및 근거

ORD 기록
ord-eedb9b22640b40bb8f4133c725dde4e3
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04988692

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