Furfurylamine → HCID 15058198, 화합물

HRID 704659노트

반응식

HRID 704659 반응식
[C:1]1([CH:7]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[O:8][C:9]2[C:14](=[O:15])[CH:13]=[C:12]([CH2:16][OH:17])O[CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:24]1[CH:28]=[C:27]([CH2:29][NH2:30])[O:26][CH:25]=1>CO.C(Cl)(Cl)Cl>[C:1]1([CH:7]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[O:8][C:9]2[C:14](=[O:15])[CH:13]=[C:12]([CH2:16][OH:17])[N:30]([CH2:29][C:27]3[O:26][CH:25]=[CH:24][CH:28]=3)[CH:10]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 2

HCID 3438FurfurylamineHCID 143063875-(benzhydryloxy)-2-(hydroxymethyl)-4H-pyran-4-one

생성물 1

HCID 15058198HCID 15058198, 화합물수율 70.2%

시약·촉매·용매 2

HCID 887Methanol용매HCID 6212Chloroform용매

실험 절차

To a solution of 3.083 g of 3-diphenylmethoxy-6-hydroxymethyl-4-pyrone in 50 ml of methanol is added 7.645 g of 2-furfurylamine at room temperature, and the mixture is stirred for 4 days. The reaction mixture is condensed under reduced pressure, and the resulting residue is dissolved in 600 ml of chloroform. The organic solution is washed with water, a saturated aqueous potassium hydrogen sulfate solution in this sequence, dried over anhydrous magnesium sulfate and condensed under reduced pressure. The resulting crystal is collected by filtration, washed with a small amount of chloroform and dried under reduced pressure to give the title compound (2.72 g).

후처리

  1. customcondensed under reduced pressure
  2. washThe organic solution is washed with water
  3. dry with materiala saturated aqueous potassium hydrogen sulfate solution in this sequence, dried over anhydrous magnesium sulfate and condensed under reduced pressure
  4. filtrationThe resulting crystal is collected by filtration
  5. washwashed with a small amount of chloroform
  6. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-fe4d0e4cc2d84ddb8fe5a06316cda6d5
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04988686

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