Potassium Hydroxide → 3-(Oxiran-2-yl)pyridine

HRID 704804노트

반응식

HRID 704804 반응식
C(OCCOC1C=CC(CCN)=CC=1)C.[C:16]([NH:26][CH2:27][CH2:28][C:29]1C=C[C:32]([OH:35])=[CH:31][CH:30]=1)(OCC1C=CC=CC=1)=O.[OH-].[K+].CS(OCCOCC)(=O)=O.C(OCCOC1C=CC(CCNC(=O)OCC2C=CC=CC=2)=CC=1)C>CS(C)=O.CO>[O:35]1[CH2:32][CH:31]1[C:30]1[CH:16]=[N:26][CH:27]=[CH:28][CH:29]=1

참가 물질

8

반응물 5

HCID 14797Potassium HydroxideHCID 14103856Benzyl [2-(4-hydroxyphenyl)ethyl]carbamateHCID 15067105HCID 15067105, 화합물HCID 20073190HCID 20073190, 화합물HCID 54264530Benzyl [p-(2-ethoxyethoxy)]phenethylcarbamate

생성물 1

HCID 133195613-(Oxiran-2-yl)pyridine

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 887Methanol용매

실험 절차

from 1.3 g of p-(2-ethoxyethoxy)-phenethylamine (prepared by the reaction of N-carbobenzoxytyramine in DMSO in the presence of potassium hydroxide with ethoxyethyl methanesulfonate and catalytic hydrogenation of the benzyl [p-(2-ethoxyethoxy)]phenethylcarbamate obtained in methanol in the presence of pd/C) and 726 mg of 3-[(RS)-2-oxiranyl]pyridine there were obtained

출처 및 근거

ORD 기록
ord-12b4ae10d71143e99f23b6e5bce018cb
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04988714

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