Pyridine → (E)-1-[3-(4-Chlorophenoxy)phenyl]buten-3-one oxime

HRID 704814

반응식

HRID 704814 반응식
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][C:7]2[CH:8]=[C:9](/[CH:13]=[CH:14]/[C:15](=O)[CH3:16])[CH:10]=[CH:11][CH:12]=2)=[CH:4][CH:3]=1.Cl.[NH2:21][OH:22].N1C=CC=CC=1>CO.CCOCC>[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][C:7]2[CH:8]=[C:9](/[CH:13]=[CH:14]/[C:15](=[N:21][OH:22])[CH3:16])[CH:10]=[CH:11][CH:12]=2)=[CH:4][CH:3]=1

참가 물질

6

반응물 3

HCID 1049PyridineHCID 443297Hydroxyamine hydrochlorideHCID 20073366(E)-1-[3-(4-Chlorophenoxy)phenyl]buten-3-one

생성물 1

HCID 86744553(E)-1-[3-(4-Chlorophenoxy)phenyl]buten-3-one oxime수율 101.3%

시약·촉매·용매 2

HCID 887Methanol용매HCID 3283Diethyl Ether용매

실험 절차

The product from step (a) (19 g) and hydroxylamine hydrochloride (6.9 g) were taken up in methanol (100 ml), pyridine (20 ml) was added and the mixture stirred for 1 hour. The mixture was then stripped, redissolved in ether (200 ml), washed with 2 N aqu. HCl and satd. aqu. NaCl, dried over MgSO4, and stripped to give the desired product (20.3 g).

후처리

  1. washwashed with 2 N aqu
  2. dry with materialNaCl, dried over MgSO4

출처 및 근거

ORD 기록
ord-8ac384bb3aa048a7a33174f8bc9c7ce6
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04988733

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