Sodium Chloride → 8-Pyrrolidinyl-5,6,7,8-tetrahydroquinoline

HRID 704854노트

반응식

HRID 704854 반응식
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[CH:7]1[C:16]2[N:15]=[CH:14][CH:13]=[CH:12][C:11]=2[CH2:10][CH2:9][CH2:8]1.[Cl-].[Na+]>O>[N:1]1([CH:7]2[C:16]3[N:15]=[CH:14][CH:13]=[CH:12][C:11]=3[CH2:10][CH2:9][CH2:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 5234Sodium ChlorideHCID 31268PyrrolidineHCID 137121808-Chloro-5,6,7,8-tetrahydroquinoline

생성물 1

HCID 139833798-Pyrrolidinyl-5,6,7,8-tetrahydroquinoline

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Over a period of 7 minutes with stirring and while allowing it to heat up, 50 ml of pyrrolidine were added to a solution of 20 g of 8-chloro-5,6,7,8-tetrahydroquinoline in 50 ml of water. The temperature reached 57° C. at the end of the introduction and stirring was continued for 1 hour at this temperature. The temperature was then allowed to return to 20° C. and the reaction medium was saturated with sodium chloride and then was extracted with ether. The combined organic phases were dried and the solvents were eliminated under reduced pressure to obtain 20.22 g or 8-pyrrolidinyl-5,6,7,8-tetrahydroquinoline in the form of an oil.

후처리

  1. temperatureto heat up
  2. customreached 57° C. at the end of the introduction
  3. stirringstirring
  4. waitwas continued for 1 hour at this temperature
  5. customto return to 20° C.
  6. extractionwas extracted with ether
  7. customThe combined organic phases were dried

출처 및 근거

ORD 기록
ord-fc1665e16535462bb4840f3eb7ec95b1
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04988810

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