Ethyl formate → 3-Formamido-3-methyl-1-butanol

HRID 704904

반응식

HRID 704904 반응식
[NH2:1][C:2]([CH3:7])([CH3:6])[CH2:3][CH2:4][OH:5].[CH:8](OCC)=[O:9]>>[CH:8]([NH:1][C:2]([CH3:7])([CH3:6])[CH2:3][CH2:4][OH:5])=[O:9]

참가 물질

3

반응물 2

HCID 8025Ethyl formateHCID 6410003-Amino-3-methylbutan-1-ol

생성물 1

HCID 200736373-Formamido-3-methyl-1-butanol

실험 절차

3-Amino-3-methyl-1-butanol (20.60 g, 0.20 mol) was added to ethyl formate (29.60 g, 0.40 mol), and the resulting clear solution was heated to reflux under nitrogen for 2 hours, and then allowed to cool to room temperature. The ethyl formate and ethanol by-product were removed by rotary evaporation (35° C., 25 Torr). The resulting oil was dried under vacuum (25° C., 0.1 Torr) to yield 25.86 g (99%).

후처리

  1. temperaturethe resulting clear solution was heated
  2. temperatureto reflux under nitrogen for 2 hours
  3. customThe ethyl formate and ethanol by-product were removed by rotary evaporation (35° C., 25 Torr)
  4. customThe resulting oil was dried under vacuum (25° C., 0.1 Torr)
  5. customto yield 25.86 g (99%)

출처 및 근거

ORD 기록
ord-a7ae87b463de419fa416f368a4dea82d
출처 데이터셋
uspto-grants-1991_01
특허 번호
US04988827

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