Acetonitrile → HCID 58452310, 화합물

HRID 70529노트

반응식

HRID 70529 반응식
C(#N)C.[C:4]([C:8]1[CH:13]=[CH:12][C:11](/[C:14](/[C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[C:21]([O:26][CH3:27])[N:20]=2)=[CH:15]\C(O)=O)=[CH:10][CH:9]=1)([CH3:7])([CH3:6])[CH3:5].[Br:28]N1C(=O)CCC1=O>C(N(CC)CC)C>[Br:28]/[CH:15]=[C:14](/[C:19]1[N:20]=[C:21]([O:26][CH3:27])[C:22]([Cl:25])=[CH:23][CH:24]=1)\[C:11]1[CH:12]=[CH:13][C:8]([C:4]([CH3:7])([CH3:6])[CH3:5])=[CH:9][CH:10]=1

참가 물질

5

반응물 3

HCID 6342AcetonitrileHCID 67184N-bromobutanimideHCID 58452337(2E)-3-(4-tert-Butylphenyl)-3-(5-chloro-6-methoxypyridin-2-yl)prop-2-enoic acid

생성물 1

HCID 58452310HCID 58452310, 화합물수율 25.4%

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

A 97% acetonitrile solution (52 mL) containing triethylamine (26 μL) was added to (2E)-3-(4-tert-butylphenyl)-3-(5-chloro-6-methoxypyridin-2-yl)prop-2-enoic acid (1.3 g). N-bromosuccinimide (806 mg) was added thereto and the mixture was stirred at room temperature for 15 minutes. The solvent was evaporated under reduced pressure from the reaction solution. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=19:1) to give the title compound as a colorless powder (363 mg, 25%).

후처리

  1. customThe solvent was evaporated under reduced pressure from the reaction solution
  2. customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=19:1)

출처 및 근거

ORD 기록
ord-3967e97791ca43dfbfb76ec8b4b55a3d
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822503B2

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