3-(Cyclohexen-1-yl)aniline → N-[3-(cyclohexen-1-yl)phenyl]-4-hydroxy-3-methoxyphenylacetamide

HRID 7062

반응식

HRID 7062 반응식
FC1C(O[C:9](=[O:20])[CH2:10][C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[C:13]([O:18][CH3:19])[CH:12]=2)=C(F)C(F)=C(F)C=1F.[C:25]1([C:31]2[CH:32]=[C:33]([CH:35]=[CH:36][CH:37]=2)[NH2:34])[CH2:30][CH2:29][CH2:28][CH2:27][CH:26]=1>C(OCC)(=O)C>[C:25]1([C:31]2[CH:32]=[C:33]([NH:34][C:9](=[O:20])[CH2:10][C:11]3[CH:16]=[CH:15][C:14]([OH:17])=[C:13]([O:18][CH3:19])[CH:12]=3)[CH:35]=[CH:36][CH:37]=2)[CH2:30][CH2:29][CH2:28][CH2:27][CH:26]=1

참가 물질

4

반응물 2

HCID 67097493-(Cyclohexen-1-yl)anilineHCID 225073804-Hydroxy-3-methoxyphenylacetic acid pentafluorophenyl ester

생성물 1

HCID 22019669N-[3-(cyclohexen-1-yl)phenyl]-4-hydroxy-3-methoxyphenylacetamide수율 86%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

반응 조건

온도
60 °C

실험 절차

4-Hydroxy-3-methoxyphenylacetic acid pentafluorophenyl ester (60 mg) and Intermediate 2 (60 mg) are dissolved in ethyl acetate, and the mixture is stirred at 60° C. for 18 hours. The solvent is evaporated under reduced pressure, and the residue is purified by silica gel column chromatography (eluent: gradient from 0% to 100% hexane/ethyl acetate) to give the title compound (50 mg).

후처리

  1. customThe solvent is evaporated under reduced pressure
  2. customthe residue is purified by silica gel column chromatography (eluent: gradient from 0% to 100% hexane/ethyl acetate)

출처 및 근거

ORD 기록
ord-cd1c80ce4ddb43ffb41ba233536d3992
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084176B2

연결된 노트

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