5-Aminobenzimidazole → 5-(4-(2-methoxyethoxy)phenyl)-1-(1H-benzo[d]imidazol-5-yl)imidazolidin-2-one

HRID 706314노트

반응식

HRID 706314 반응식
FC(F)(F)C([O-])=O.[NH2:8][C:9]1[CH:17]=[CH:16][C:12]2[N:13]=[CH:14][NH:15][C:11]=2[CH:10]=1.[CH3:18][O:19][CH2:20][CH2:21][O:22][C:23]1[CH:30]=[CH:29][C:26]([CH:27]=O)=[CH:25][CH:24]=1.[Si](C#N)(C)(C)C.[N:37]1([C:42](N2C=CN=C2)=[O:43])C=CN=[CH:38]1>>[CH3:18][O:19][CH2:20][CH2:21][O:22][C:23]1[CH:30]=[CH:29][C:26]([CH:27]2[N:8]([C:9]3[CH:17]=[CH:16][C:12]4[NH:13][CH:14]=[N:15][C:11]=4[CH:10]=3)[C:42](=[O:43])[NH:37][CH2:38]2)=[CH:25][CH:24]=1

참가 물질

6

반응물 5

HCID 136235-AminobenzimidazoleHCID 682631,1'-CarbonyldiimidazoleHCID 82115Trimethylsilyl cyanideHCID 84468TrifluoroacetateHCID 64855604-(2-Methoxyethoxy)benzaldehyde

생성물 1

HCID 1784961085-(4-(2-methoxyethoxy)phenyl)-1-(1H-benzo[d]imidazol-5-yl)imidazolidin-2-one

실험 절차

The compound was synthesized as trifluoroacetate salt starting from 5-aminobenzimidazole (1.3 gmg, 9.99 mmol), 4-(2-methoxyethoxy)benzaldehyde (1.5 g, 8.33 mmol), TMSCN (1.64 mL, 16.66 mmol) 10% Pd—C (200 mg), TEA (2.5 mL, 18.40 mmol), di-(imidazol-1-yl)methanone (1.192 g, 7.36 mmol), as described in method 2. The product was purified by means of preparative HPLC.

후처리

  1. customThe product was purified by means of preparative HPLC

출처 및 근거

ORD 기록
ord-313b66a7b08449b9aa0dc9c3f7dc27e2
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09173885B2

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