N-bromobutanimide → HCID 178498689, 화합물

HRID 706581노트

반응식

HRID 706581 반응식
[CH3:1][O:2][C:3]([C:5]1[C:6]2[CH:7]=[N:8][NH:9][C:10]=2[CH:11]=[CH:12][C:13]=1[F:14])=[O:4].[Br:15]N1C(=O)CCC1=O>CN(C=O)C>[Br:15][C:7]1[C:6]2[C:5]([C:3]([O:2][CH3:1])=[O:4])=[C:13]([F:14])[CH:12]=[CH:11][C:10]=2[NH:9][N:8]=1

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 593345601383474-59-6

생성물 1

HCID 178498689HCID 178498689, 화합물수율 69%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of methyl-5-fluoro-1H-indazole-4-carboxylate (0.475 g, 2.45 mmol) in 25 mL of DMF was added N-bromosuccinimide (0.566 g, 3.18 mmol). This mixture was stirred at ambient temperature for one hour, then quenched with water. This mixture was extracted with EtOAc, and the combined organic extracts washed with brine, dried over sodium sulfate and concentrated under reduced pressure. Column chromatography (1:1 EtOAc/Hexane) afforded 0.459 g (69%) of the title compound.

후처리

  1. customquenched with water
  2. extractionThis mixture was extracted with EtOAc
  3. washthe combined organic extracts washed with brine
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-acba70997fb7495e8c4fe10424b11020
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09174981B2

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