Ethanol → 7-Fluoroimidazo[1,2-a]pyridine-3-carboxylic acid

HRID 706586노트

반응식

HRID 706586 반응식
[F:1][C:2]1[CH:7]=[CH:6][N:5]2[C:8]([C:11]([O:13]CC)=[O:12])=[CH:9][N:10]=[C:4]2[CH:3]=1.O1CCCC1.C(O)C.O.[OH-].[Li+]>O>[F:1][C:2]1[CH:7]=[CH:6][N:5]2[C:8]([C:11]([OH:13])=[O:12])=[CH:9][N:10]=[C:4]2[CH:3]=1

참가 물질

6

반응물 4

HCID 702EthanolHCID 8028TetrahydrofuranHCID 168937Lithium hydroxide, monohydrateHCID 67259301Ethyl 7-fluoroimidazo[1,2-a]pyridine-3-carboxylate

생성물 1

HCID 672607377-Fluoroimidazo[1,2-a]pyridine-3-carboxylic acid수율 78.8%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Ethyl 7-fluoroimidazo[1,2-a]pyridine-3-carboxylate (8 g; 44.4 mmol) was mixed with tetrahydrofuran (225 mL), ethanol (110 mL) and water (55 mL). Lithium hydroxide monohydrate (0.962 g; 22.9 mmol) was added. The mixture was stirred at ambient temperature overnight. The mixture concentrated under reduced pressure to remove tetrahydrofuran and ethanol. 2 N hydrochloric acid was added to aqueous mixture to adjust to pH 3. A white precipitate formed and was filtered off with drying under high vacuum overnight to give 7-fluoroimidazo[1,2-a]pyridine-3-carboxylic acid as a white solid (6.3 g).

후처리

  1. concentrationThe mixture concentrated under reduced pressure
  2. customto remove tetrahydrofuran and ethanol
  3. addition2 N hydrochloric acid was added to aqueous mixture
  4. customA white precipitate formed
  5. filtrationwas filtered off
  6. customwith drying under high vacuum overnight

출처 및 근거

ORD 기록
ord-ef13558cdd4041288520b360c2b1585f
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09174981B2

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