Ethanol → 7-Fluoroimidazo[1,2-a]pyridine-3-carboxylic acid

HRID 706618노트

반응식

HRID 706618 반응식
[F:1][C:2]1[CH:7]=[CH:6][N:5]2[C:8]([C:11]([O:13]CC)=[O:12])=[CH:9][N:10]=[C:4]2[CH:3]=1.O1CCCC1.C(O)C.O.[OH-].[Li+]>O>[F:1][C:2]1[CH:7]=[CH:6][N:5]2[C:8]([C:11]([OH:13])=[O:12])=[CH:9][N:10]=[C:4]2[CH:3]=1

참가 물질

6

반응물 4

HCID 702EthanolHCID 8028TetrahydrofuranHCID 168937Lithium hydroxide, monohydrateHCID 67259301Ethyl 7-fluoroimidazo[1,2-a]pyridine-3-carboxylate

생성물 1

HCID 672607377-Fluoroimidazo[1,2-a]pyridine-3-carboxylic acid수율 78.8%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Ethyl 7-fluoroimidazo[1,2-a]pyridine-3-carboxylate (8 g; 44.4 mmol) was mixed with tetrahydrofuran (225 mL), ethanol (110 mL) and water (55 mL). Lithium hydroxide monohydrate (0.962 g; 22.9 mmol) was added. The mixture was stirred at ambient temperature overnight. The mixture concentrated under reduced pressure to remove tetrahydrofuran and ethanol. Hydrochloric acid (2N) was added to aqueous mixture to adjust to pH 3. White precipitate formed and was filtered off with drying under high vacuum overnight to give 7-fluoroimidazo[1,2-a]pyridine-3-carboxylic acid as a white solid (6.3 g).

후처리

  1. concentrationThe mixture concentrated under reduced pressure
  2. customto remove tetrahydrofuran and ethanol
  3. additionHydrochloric acid (2N) was added to aqueous mixture
  4. customWhite precipitate
  5. customformed
  6. filtrationwas filtered off
  7. customwith drying under high vacuum overnight

출처 및 근거

ORD 기록
ord-fb270e9640ee40cd8b25ad7c04376fb6
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09174981B2

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