Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-methyl-1-((6-methylpyridin-2-yl)methyl)-4-nitro-1H-indazole → 3-methyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-methyl-1-((6-methylpyridin-2-yl)methyl)-4-nitro-1H-indazole | HCID 67259299 | — |
| 촉매 | Palladium hydroxide | HCID 9942167 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3-methyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-amine | HCID 67260938 | 75.1% |
반응 단계
A suspension of 3-methyl-1-((6-methylpyridin-2-yl)methyl)-4-nitro-1H-indazole (54 mg, 0.19 mmol) in absolute EtOH (1.5 mL) was treated at ambient temperature with 10% palladium hydroxide on carbon (27 mg, 0.019 mmol). The mixture was stirred at ambient temperature under a hydrogen atmosphere for 16 hours, and then filtered through a Celite® pad, washing with EtOH. The filtrate was concentrated under reduced pressure to afford the product (36 mg) as a yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09174981B2 |
| 출처 데이터셋 | uspto-grants-2015_11 |
| ORD ID | ord-ccd8ef8d898f4478bffd9b68217a7e77 |
| 출처 메모 | uspto-grants-2015_11 |