Water → (4-(Methoxymethyl)cyclohexyl)methanamine
반응식
[CH3:1][O:2][CH2:3][CH:4]1[CH2:9][CH2:8][CH:7]([C:10]#[N:11])[CH2:6][CH2:5]1.[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+].O>O1CCCC1>[CH3:1][O:2][CH2:3][CH:4]1[CH2:9][CH2:8][CH:7]([CH2:10][NH2:11])[CH2:6][CH2:5]1참가 물질
6
실험 절차
To a solution of EXAMPLE 374D (460 mg) in tetrahydrofuran (15 mL) was added 2M lithium aluminum hydride in tetrahydrofuran (2.252 mL) slowly. The reaction mixture was stirred at room temperature for 1 hour, refluxed for 1 hour and cooled. 2 ml of 2M aqueous NaOH and water (5 mL) was added. The solid was filtered off and washed with ether. The filtrate was concentrated. The residue was mixed with dichloromethane (50 mL) and the resulting mixture was dried over Na2SO4 and concentrated to provide the title compound.
후처리
- temperaturerefluxed for 1 hour
- temperaturecooled
- filtrationThe solid was filtered off
- washwashed with ether
- concentrationThe filtrate was concentrated
- additionThe residue was mixed with dichloromethane (50 mL)
- dry with materialthe resulting mixture was dried over Na2SO4
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-f22c102b86844a20a94f9d57d89b96a5
- 출처 데이터셋
- uspto-grants-2015_11
- 특허 번호
- US09174982B2
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