Trifluoroacetic acid → 3-Cyclopropyl-6-[[4-(cyclopropylsulfonyl)phenyl](2,4-di fluorophenoxy)methyl]pyridin-2(1H)-one

HRID 70717노트

반응식

HRID 70717 반응식
FC(F)(F)C(O)=O.[CH:8]1([C:11]2[C:12]([O:39]CC3C=CC(OC)=CC=3)=[N:13][C:14]([CH:17]([C:27]3[CH:32]=[CH:31][C:30]([S:33]([CH:36]4[CH2:38][CH2:37]4)(=[O:35])=[O:34])=[CH:29][CH:28]=3)[O:18][C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:20]=3[F:26])=[CH:15][CH:16]=2)[CH2:10][CH2:9]1>C(Cl)(Cl)Cl>[CH:8]1([C:11]2[C:12](=[O:39])[NH:13][C:14]([CH:17]([C:27]3[CH:28]=[CH:29][C:30]([S:33]([CH:36]4[CH2:38][CH2:37]4)(=[O:35])=[O:34])=[CH:31][CH:32]=3)[O:18][C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:20]=3[F:26])=[CH:15][CH:16]=2)[CH2:9][CH2:10]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 673995783-Cyclopropyl-6-{[4-(cyclopropylsulfonyl)phenyl](2,4-difluorophenoxy)methyl}-2-[(4-methoxybenzyl)oxy]pyridine

생성물 1

HCID 584523163-Cyclopropyl-6-[[4-(cyclopropylsulfonyl)phenyl](2,4-di fluorophenoxy)methyl]pyridin-2(1H)-one수율 74.4%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Trifluoroacetic acid (50 mg) was added to a solution of 3-cyclopropyl-6-{[4-(cyclopropylsulfonyl)phenyl](2,4-difluorophenoxy)methyl}-2-[(4-methoxybenzyl)oxy]pyridine (90 mg) in chloroform (5 mL), and the mixture was stirred at room temperature for two hours. The reaction solution was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=88:12→0:100) to give the title compound as a yellow powder (53 mg, 74%).

후처리

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customThe resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=88:12→0:100)

출처 및 근거

ORD 기록
ord-f6090705c34d44e294452ccad8fe1e87
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822503B2

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