3-Aminopyridine → 2-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-N-pyridin-3-ylacetamide

HRID 707189

반응식

HRID 707189 반응식
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[N:12]=[C:11]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)[N:10]=[C:9]([C:19]3[CH:24]=[CH:23][C:22]([CH2:25][C:26]([OH:28])=O)=[CH:21][CH:20]=3)[N:8]=2)[CH2:3][CH2:2]1.[NH2:29][C:30]1[CH:31]=[N:32][CH:33]=[CH:34][CH:35]=1>>[N:4]1([C:7]2[N:12]=[C:11]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)[N:10]=[C:9]([C:19]3[CH:20]=[CH:21][C:22]([CH2:25][C:26]([NH:29][C:30]4[CH:31]=[N:32][CH:33]=[CH:34][CH:35]=4)=[O:28])=[CH:23][CH:24]=3)[N:8]=2)[CH2:5][CH2:6][O:1][CH2:2][CH2:3]1

참가 물질

3

반응물 2

HCID 100093-AminopyridineHCID 674399772-(4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)phenyl)acetic acid

생성물 1

HCID 674397432-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-N-pyridin-3-ylacetamide수율 44%

실험 절차

The title compound was prepared by following the procedure of example 473 step 3 using 2-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl) acetic acid and 3-aminopyridine. Yield 21 mg, 44% yield; HPLC: Rt=1.91 min; MS 462 [M+H].

출처 및 근거

ORD 기록
ord-0c9815b175294fff85427a473340669d
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09174963B2

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