(2-Amino-4-chlorophenyl)methanol → 2-Amino-4-chlorobenzaldehyde

HRID 707218

반응식

HRID 707218 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][OH:10]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]=[O:10]

참가 물질

4

반응물 1

HCID 4134900(2-Amino-4-chlorophenyl)methanol

생성물 1

HCID 112521382-Amino-4-chlorobenzaldehyde

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6212Chloroform용매

실험 절차

(2-amino-4-chlorophenyl)methanol (10.08 g, 64.0 mmol) was suspended in chloroform (250 mL) and treated with manganese dioxide (15.87 g, 183 mmol). The mixture was stirred vigorously and heated at reflux. The oxidation was followed by TLC and found to be complete after 1 hour. The suspension was filtered through a pad of CELITE™ and evaporated to dryness under reduced pressure. Further drying under high vacuum gave a dark red solid which was used in the next step without further purification.

후처리

  1. temperatureheated
  2. temperatureat reflux
  3. filtrationThe suspension was filtered through a pad of CELITE™
  4. customevaporated to dryness under reduced pressure
  5. customFurther drying under high vacuum
  6. customgave a dark red solid which
  7. customwas used in the next step without further purification

출처 및 근거

ORD 기록
ord-2cf16fb38d554c9fa404efcf50bdba68
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09174992B2

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