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Water → Tert-butyl 4-(2-(3-chloropyrazin-2-YL)-2-methylpropanamido)piperidine-1-carboxylate

HRID 707278
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HRID 707278 반응식
[Cl:1][C:2]1[C:3]([C:8]([CH3:13])([CH3:12])[C:9]([OH:11])=O)=[N:4][CH:5]=[CH:6][N:7]=1.[NH2:14][CH:15]1[CH2:20][CH2:19][N:18]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:17][CH2:16]1.CCN(C(C)C)C(C)C.O>CN(C=O)C>[Cl:1][C:2]1[C:3]([C:8]([CH3:13])([CH3:12])[C:9]([NH:14][CH:15]2[CH2:16][CH2:17][N:18]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:19][CH2:20]2)=[O:11])=[N:4][CH:5]=[CH:6][N:7]=1
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참가 물질

6

반응물 4

HCID 962WaterHCID 81531DiisopropylethylamineHCID 12682914-Amino-1-Boc-piperidineHCID 866941182-(3-Chloropyrazin-2-yl)-2-methylpropanoic acid

생성물 1

HCID 86694146Tert-butyl 4-(2-(3-chloropyrazin-2-YL)-2-methylpropanamido)piperidine-1-carboxylate

시약·촉매·용매 1

HCID 6228
Dimethylformamide
용매

실험 절차

A mixture of 2-(3-chloropyrazin-2-yl)-2-methylpropanoic acid (2.0 g, 9.97 mmol), tert-butyl 4-amino-1-piperidinecarboxylate (2.396 g, 11.96 mmol), DIEA (2.61 ml, 14.95 mmol), and hatu (4.17 g, 10.97 mmol) in DMF (30 mL) was stirred at RT overnight. The reaction mixture was then heated to 55° C. for 4 h, cooled, and H2O was added, the light brown solid was collected, dried and used in the next step (3.1 g, 81%). MS (M+1): 383.1

후처리

  1. temperatureThe reaction mixture was then heated to 55° C. for 4 h
  2. temperaturecooled
  3. customthe light brown solid was collected
  4. customdried

출처 및 근거

ORD 기록
ord-32bab38d8b9442eeb70b01495f62e8f5
출처 데이터셋
uspto-grants-2015_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09174992B2

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