Hydrochloric Acid → HCID 67477378, 화합물

HRID 707342노트

반응식

HRID 707342 반응식
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[N:11]1[CH2:14][CH:13]([NH:15]C(=O)OC(C)(C)C)[CH2:12]1.[ClH:23]>>[ClH:23].[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[N:11]1[CH2:12][CH:13]([NH2:15])[CH2:14]1

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 58547859HCID 58547859, 화합물

생성물 1

HCID 67477378HCID 67477378, 화합물수율 100%

실험 절차

To tert-butyl (1-(quinolin-2-yl)azetidin-3-yl)-carbamate (1.14 g, 3.84 mmol) was added hydrogen chloride (4 M solution in methanol, 20 mL). The reaction mixture was stirred at room temperature for 1 hour. It was concentrated to give 1-(quinolin-2-yl)azetidin-3-amine hydrochloride (0.90 g, 3.84 mmol, 100% yield) which was used in the next step without further purification.

후처리

  1. concentrationIt was concentrated

출처 및 근거

ORD 기록
ord-665a3c4677994070877a6fcc6b0059de
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09174992B2

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