Methylhydrazine → (R)-tert-butyl 2-(aminooxy)propanoate

HRID 708404노트

반응식

HRID 708404 반응식
O=C1C2C(=CC=CC=2)C(=O)[N:3]1[O:12][C@H:13]([CH3:21])[C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15].CNN>C(Cl)Cl>[NH2:3][O:12][C@H:13]([CH3:21])[C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15]

참가 물질

4

반응물 2

HCID 6061MethylhydrazineHCID 108808241,1-Dimethylethyl (2R)-2-((1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy)propanoate

생성물 1

HCID 118379664(R)-tert-butyl 2-(aminooxy)propanoate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

To a solution of (R)-tert-butyl 2-((1,3-dioxoisoindolin-2-yl)oxy)propanoate (69.6 mg, 0.239 mmol) in DCM (478 μL) at 0° C. was added methyl hydrazine (12.8 μL, 0.239 mmol). After stirring for 3 h at 0° C., the solids were filtered off and the filtrate was concentrated in vacuo, affording the title compound (assumed quantitative) as a clear oil.

후처리

  1. filtrationthe solids were filtered off
  2. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-9a2b73e04c494b04838af19c707850ca
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09174978B2

반응 노트

불러오는 중…