Sodium Hydroxide → HCID 178524643, 화합물

HRID 70898노트

반응식

HRID 70898 반응식
[OH:1][C:2]1[CH:6]=[C:5]([C:7]([O:9]C)=[O:8])[S:4][N:3]=1.[OH-].[Na+]>CO>[OH:1][C:2]1[CH:6]=[C:5]([C:7]([OH:9])=[O:8])[S:4][N:3]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 178498604HCID 178498604, 화합물

생성물 1

HCID 178524643HCID 178524643, 화합물수율 99.6%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of methyl 3-hydroxyisothiazole-5-carboxylate (300 mg, 1.73 mmol) in MeOH (2 mL) is added 1N NaOH (6 mL, 6 mmol). After stirring at room temperature for 2 hours, the crude is concentrated under reduced pressure to remove MeOH and is diluted with EtOAc. The organic layer is washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure to give 3-hydroxyisothiazole-5-carboxylic acid (250 mg).

후처리

  1. concentrationthe crude is concentrated under reduced pressure
  2. customto remove MeOH
  3. additionis diluted with EtOAc
  4. washThe organic layer is washed with brine
  5. dry with materialdried over Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-678f4bf1923a48c7820e53ed6a2bdcf2
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822534B2

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