Hydrochloric Acid → HCID 76511213, 화합물

HRID 709261노트

반응식

HRID 709261 반응식
[CH3:1][C:2]([S:29]([CH3:32])(=[O:31])=[O:30])([CH2:13][CH2:14][N:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[C:17]([CH3:27])[C:16]1=[O:28])[C:3]([NH:5][O:6]C1CCCCO1)=[O:4].Cl.CO>C(Cl)Cl>[OH:6][NH:5][C:3](=[O:4])[C:2]([CH3:1])([S:29]([CH3:32])(=[O:31])=[O:30])[CH2:13][CH2:14][N:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)=[C:17]([CH3:27])[C:16]1=[O:28]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 866719522-methyl-4-(3-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

생성물 1

HCID 76511213HCID 76511213, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2-methyl-4-(3-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide (137 mg, 0.296 mmol) was dissolved in methylene chloride (2 mL) at ambient temperature. To this solution was added HCl (4M in 1,4-dioxane, 2.22 mL, 8.88 mmol) and the slurry was stirred at ambient temperature for 15 minutes. Methanol (1 mL) was added followed by silica gel and the mixture was concentrated to dryness. Crude material was purified via silica gel chromatography eluting with methylene chloride/methanol to afford N-hydroxy-2-methyl-4-(3-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)-2-(methylsulfonyl)butanamide as a solid. 65.8 mg

후처리

  1. concentrationthe mixture was concentrated to dryness
  2. customCrude material was purified via silica gel chromatography
  3. washeluting with methylene chloride/methanol

출처 및 근거

ORD 기록
ord-2659be4b1ce54e299002709c9a64ac4b
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09180123B2

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