Hydrochloric Acid → HCID 178508813, 화합물

HRID 709942노트

반응식

HRID 709942 반응식
C[O:2][C:3]1[N:8]=[CH:7][N:6]=[C:5]([NH2:9])[C:4]=1[C:10]([F:13])([F:12])[F:11].Cl>O1CCOCC1>[NH2:9][C:5]1[N:6]=[CH:7][N:8]=[C:3]([OH:2])[C:4]=1[C:10]([F:13])([F:12])[F:11]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 666076446-methoxy-5-(trifluoromethyl)-4-Pyrimidinamine

생성물 1

HCID 178508813HCID 178508813, 화합물

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

반응 조건

온도
90 °C

실험 절차

To a solution of 6-methoxy-5-(trifluoromethyl)pyrimidin-4-amine (N-3) (420 mg, 2.18 mmol) in 1,4-dioxane (10 mL), concentrated HCl (1.81 mL, 21.8 mmol) is added and the resulting mixture is stirred at 90° C. for 3 h. The mixture is allowed to cool to RT and then concentrated in vacuo to afford the product, 6-amino-5-(trifluoromethyl)pyrimidin-4-ol (N-4) as yellowish solid.

후처리

  1. temperatureto cool to RT
  2. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-93cef1c247d94ad1acc7bf078dd75114
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181221B2

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