2-Chloro-4-((6-nitropyridin-3-yl)oxy)pyridine → 5-(2-Chloropyridin-4-yloxy)pyridin-2-amine

HRID 709965노트

반응식

HRID 709965 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[CH:10]=[N:11][C:12]([N+:15]([O-])=O)=[CH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=1>CO.[Ni]>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[N:11][CH:10]=2)[CH:5]=[CH:4][N:3]=1

참가 물질

4

반응물 1

HCID 593227792-Chloro-4-((6-nitropyridin-3-yl)oxy)pyridine

생성물 1

HCID 593227885-(2-Chloropyridin-4-yloxy)pyridin-2-amine수율 105.8%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

A solution of 2-chloro-4-((6-nitropyridin-3-yl)oxy)pyridine (20.0 g, 79 mmol) in MeOH (40 mL) was hydrogenated in presence of Raney Nickel (2.00 g, 34.1 mmol) at 40 psi for 3 h. The catalyst was removed via filtration, rinsed with MeOH and the filtrate concentrated to dryness to afford 5-((2-chloropyridin-4-yl)oxy)pyridin-2-amine (18.52 g, 105%) as a brown solid. MS (ESI) m/z: 222.0 (M+H+).

후처리

  1. customThe catalyst was removed via filtration
  2. washrinsed with MeOH
  3. concentrationthe filtrate concentrated to dryness

출처 및 근거

ORD 기록
ord-ddd739c9f1204cf885f3409b2c36c287
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181223B2

반응 노트

불러오는 중…