Trifluoroacetic acid → (S)-5-((3,4-Dimethoxyphenoxy)methyl)-1-methyl-3-(pyrrolidin-2-yl)-1H-pyrazole

HRID 710052노트

반응식

HRID 710052 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:26]=[CH:27][C:28]=1[O:29][CH3:30])[O:6][CH2:7][C:8]1[N:12]([CH3:13])[N:11]=[C:10]([C@@H:14]2[CH2:18][CH2:17][CH2:16][N:15]2C(OC(C)(C)C)=O)[CH:9]=1.C(O)(C(F)(F)F)=O>C(Cl)(Cl)Cl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:26]=[CH:27][C:28]=1[O:29][CH3:30])[O:6][CH2:7][C:8]1[N:12]([CH3:13])[N:11]=[C:10]([C@@H:14]2[CH2:18][CH2:17][CH2:16][NH:15]2)[CH:9]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 86706764(S)-t-Butyl 2-(5-((3,4-dimethoxyphenoxy)methyl)-1-methyl-1H-pyrazol-3-yl)pyrrolidine-1-carboxylate

생성물 1

HCID 86706765(S)-5-((3,4-Dimethoxyphenoxy)methyl)-1-methyl-3-(pyrrolidin-2-yl)-1H-pyrazole수율 102%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a CHCl3 (1.0 mL) solution of the compound (365 mg) obtained in Example 13-(2), TFA (5.0 mL) was added at 0° C. and the mixture was stirred at room temperature for 2 hours. After concentrating the reaction mixture, saturated aqueous sodium bicarbonate (50 mL) was added and the organic layer extracted with CHCl3 (50 mL×2) was dried (Na2SO4), filtered and concentrated to give the titled compound (283 mg, pale brown oil.)

후처리

  1. concentrationAfter concentrating the reaction mixture, saturated aqueous sodium bicarbonate (50 mL)
  2. additionwas added
  3. extractionthe organic layer extracted with CHCl3 (50 mL×2)
  4. dry with materialwas dried (Na2SO4)
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-c2f5bbf9c3234ffd97451368cc61d6e9
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181229B2

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