Hydrochloric Acid → 1-Amino-3-(3,4-dimethoxyphenoxy)propan-2-one hydrochloride

HRID 710062노트

반응식

HRID 710062 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:14]=[CH:15][C:16]=1[O:17][CH3:18])[O:6][CH2:7][C:8](=[O:13])[CH2:9][N+:10]([O-])=O.[ClH:19].[H][H]>[Pd].CO>[ClH:19].[NH2:10][CH2:9][C:8](=[O:13])[CH2:7][O:6][C:5]1[CH:14]=[CH:15][C:16]([O:17][CH3:18])=[C:3]([O:2][CH3:1])[CH:4]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 867067741-(3,4-Dimethoxyphenoxy)-3-nitropropan-2-oneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 867067751-Amino-3-(3,4-dimethoxyphenoxy)propan-2-one hydrochloride

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a MeOH (7 ml) solution of the compound (0.660 g) obtained in Example 19-(2), 10% Pd—C (0.330 g) and an aqueous solution of 1N HCl (14 ml) were added and the mixture was stirred at room temperature for 5 hours in a hydrogen gas atmosphere. The insoluble matter was filtered off and the filtrate was concentrated to give the titled compound (0.715 g, brown amorphous.)

후처리

  1. filtrationThe insoluble matter was filtered off
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-0343177e56eb4de2aea60c267dd6a7c7
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181229B2

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