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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 710195생성일: 2026년 10월 25일

5-(But-2-ynyloxy)pyrazine-2-carboxylic acid → 5-But-2-ynyloxy-pyrazine-2-carboxylic acid [3-((4S,4aR,7aR)-2-amino-5,5-difluoro-4-methyl-4,4a,5,6,7,7a-hexahydro-cyclopenta[e][1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide

https://huagongshe.com/reaction/710195

반응식

참여 물질

역할이름HCID투입량
반응물5-(But-2-ynyloxy)pyrazine-2-carboxylic acidHCID 58448677—
반응물(4S,4aR,7aR)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-4,4a,5,6,7,7a-hexahydro-cyclopenta[e][1,3]oxazin-2-ylamineHCID 90021263—
생성물5-But-2-ynyloxy-pyrazine-2-carboxylic acid [3-((4S,4aR,7aR)-2-amino-5,5-difluoro-4-methyl-4,4a,5,6,7,7a-hexahydro-cyclopenta[e][1,3]oxazin-4-yl)-4-fluoro-phenyl]-amideHCID 72706009—

반응 단계

The coupling of (4S,4aR,7aR)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-4,4a,5,6,7,7a-hexahydro-cyclopenta[e][1,3]oxazin-2-ylamine (intermediate XIIIa-1) and 5-but-2-ynyloxy-pyrazine-2-carboxylic acid (CAS 1221447-98-814) following procedure Q yielded the title compound as an amorphous colorless material (34% yield). MS: m/z=474.2 [M+H]+.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09181232B2
출처 데이터셋uspto-grants-2015_11
ORD IDord-977f30d217fb42f19353fb3224212237
출처 메모uspto-grants-2015_11