3-Chloro-4-ethoxybenzaldehyde → 4-Butoxy-3-chlorobenzoic acid

HRID 710424

반응식

HRID 710424 반응식
[CH2:1]([O:5][C:6]1[CH:13]=[CH:12][C:9]([CH:10]=[O:11])=[CH:8][C:7]=1[Cl:14])[CH2:2][CH2:3][CH3:4].ClC1C=C(C=CC=1OCC)C=[O:20]>>[CH2:1]([O:5][C:6]1[CH:13]=[CH:12][C:9]([C:10]([OH:20])=[O:11])=[CH:8][C:7]=1[Cl:14])[CH2:2][CH2:3][CH3:4]

참가 물질

3

반응물 2

HCID 47700353-Chloro-4-ethoxybenzaldehydeHCID 547952064-Butoxy-3-chlorobenzaldehyde

생성물 1

HCID 211054764-Butoxy-3-chlorobenzoic acid수율 85%

실험 절차

When the product of Step A was substituted for 3-chloro-4-ethoxybenzaldehyde in Example 49, Step A the identical process afforded the title compound in 85% yield. 1H-NMR (CDCl3) 0.96 (tr, 3H, J=7.38 Hz); 1.46-1.57 (m, 2H); 1.59-2.77 (m, 2H); 4.1 (tr, 2H, J=6.45 Hz); 6.93 (d, 1H, J=8.67 Hz); 7.96 (dd, 1H, J=8.64, 2.1 Hz); 8.1 (d, 1H, J=2.07 Hz).

출처 및 근거

ORD 기록
ord-78fbe9da51ab41688f41d4728e495fc5
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181182B2

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