3-Methylcatechol → 3-Methylveratrole

HRID 71052

반응식

HRID 71052 반응식
[CH3:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:4]([OH:5])[C:3]=1O.[CH3:10]I.[C:12]([O-:15])([O-])=O.[K+].[K+]>CC(C)=O>[CH3:10][O:5][C:4]1[CH:6]=[CH:7][CH:8]=[C:2]([CH3:1])[C:3]=1[O:15][CH3:12]

참가 물질

5

반응물 3

HCID 3403-MethylcatecholHCID 6328Methyl iodideHCID 11430Potassium Carbonate

생성물 1

HCID 782153-Methylveratrole

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

In a round bottom flask, 3-methyl catechol (5.0 g, 40.3 mmol), MeI (22.3 g, 157.1 mmol), and K2CO3 (18.9 g, 136.9 mmol) were dissolved in acetone (20.0 ml). The reaction mixture was stirred at room temperature for 1 h, then at 60° C. for overnight. The reaction mixture was concentrated and chromatographed on silica gel using EtOAc/Hexane (5:95). A pale yellow liquid was isolated in 100% (6.13 g). The characterization of the compound matched previous report: Xing, L.; Wang, X.; Cheng, X.; Zhu, R.; Liu, B.; Hu, Y. Tetrahedron Letters 2007, 63, (38), 9382-9386.

후처리

  1. waitat 60° C. for overnight
  2. concentrationThe reaction mixture was concentrated
  3. customchromatographed on silica gel
  4. customA pale yellow liquid was isolated in 100% (6.13 g)

출처 및 근거

ORD 기록
ord-5680a16de7274cb5aacf4ba0058eddff
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822720B2

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