Hydrogen Bromide → 1-(2-Bromoethyl)-4-chlorobenzene

반응식

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8](O)[CH3:9])=[CH:4][CH:3]=1.[BrH:11]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][Br:11])=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 260Hydrogen Bromide

HCID 18825Benzenemethanol, 4-chloro-alpha-methyl-

생성물 1

HCID 230291-(2-Bromoethyl)-4-chlorobenzene

실험 절차

In a 65 mL glass pressure vessel, 4-chlorophenylethanol (32.725 g, 209 mmol) was warmed to between 90 and 100° C. The vessel was charged with hydrogen bromide gas and the mixture was stirred at +1.38 to +1.93 bar for 4.5 h. The pressure was released and the reaction showed 99.18% conversion by HPLC. The mixture was allowed to cool to room temperature to leave 2-(4-chlorophenyl)ethyl bromide as a brown liquid (53.735 g).

출처 및 근거

ORD 기록: ord-4d1a51bd11334accb7757aef65b5f025
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08822727B2

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