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Sodium Hydroxide → 3-(2,6-difluoropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine

HRID 710928
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HRID 710928 반응식
[F:1][C:2]1[CH:7]=[C:6]([C:8]2[C:16]3[C:11](=[N:12][CH:13]=[CH:14][CH:15]=3)[N:10](S(C3C=CC=CC=3)(=O)=O)[CH:9]=2)[CH:5]=[C:4]([F:26])[N:3]=1.[OH-].[Na+]>O1CCOCC1>[F:26][C:4]1[CH:5]=[C:6]([C:8]2[C:16]3[C:11](=[N:12][CH:13]=[CH:14][CH:15]=3)[NH:10][CH:9]=2)[CH:7]=[C:2]([F:1])[N:3]=1
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참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 674403733-(2,6-difluoropyridin-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

생성물 1

HCID 674419563-(2,6-difluoropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A mixture of EXAMPLE 56A (8.01 g, 21.6 mmol) and 20% aqueous sodium hydroxide (12 mL, 21.6 mmol) in 1,4-dioxane (75 mL) was heated at 50° C. for 90 minutes. The mixture was concentrated and the residue triturated with water, filtered, and concentrated to give the title compound.

후처리

  1. concentrationThe mixture was concentrated
  2. customthe residue triturated with water
  3. filtrationfiltered
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-0272b5da270b44f2ad061e3dd1d0b70f
출처 데이터셋
uspto-grants-2015_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09181246B2

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