Triethylamine → HCID 28787470, 화합물

HRID 711218노트

반응식

HRID 711218 반응식
[NH:1]1[CH2:6][CH2:5][S:4][CH2:3][CH2:2]1.Cl[C:8]1[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[CH:10][N:9]=1.C(N(CC)CC)C>C(O)CCC>[S:4]1[CH2:5][CH2:6][N:1]([C:8]2[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[CH:10][N:9]=2)[CH2:2][CH2:3]1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 67164ThiomorpholineHCID 51520946-Chloro-3-pyridinecarbonitrile

생성물 1

HCID 28787470HCID 28787470, 화합물

시약·촉매·용매 1

HCID 2631-Butanol용매

반응 조건

온도
100 °C

실험 절차

To a round bottom flask was added thiomorpholine 8-1 (3.6 g, 34.8 mmol), 6-chloronicotinonitrile 8-2 (4.0 g, 29 mmol), triethylamine (8 mL, 58 mmol) and butanol (10 mL). The reaction was stirred at 100° C. for 1 hour. After cooling to room temperature, the reaction formed a solid cake. The cake was triturated in 50 mL H2O at 100° C. After cooling, the solid was collected by filtration to give 6-thiomorpholinonicotinonitrile 8-3 as an off-white solid. MS m/z 206.1 (M+1).

후처리

  1. temperatureAfter cooling to room temperature
  2. customthe reaction formed a solid cake
  3. customThe cake was triturated in 50 mL H2O at 100° C
  4. temperatureAfter cooling
  5. filtrationthe solid was collected by filtration

출처 및 근거

ORD 기록
ord-be08e873d5954a018ab901a065b4c549
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181235B2

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