Ammonium → HCID 43528580, 화합물

HRID 711219노트

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HRID 711219 반응식
[S:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][N:8]=2)[CH2:3][CH2:2]1.[NH4+]>CO.C1COCC1.[Ni]>[S:1]1[CH2:6][CH2:5][N:4]([C:7]2[N:8]=[CH:9][C:10]([CH2:11][NH2:12])=[CH:13][CH:14]=2)[CH2:3][CH2:2]1

참가 물질

6

반응물 2

HCID 223AmmoniumHCID 28787470HCID 28787470, 화합물

생성물 1

HCID 43528580HCID 43528580, 화합물

시약·촉매·용매 3

HCID 935Nickel촉매HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
35 °C

실험 절차

To the solution of 6-thiomorpholinonicotinonitrile 8-3 (1.0 g, 4.8 mmol) in methanol (15 ml) and THF (9 ml) was added Raney-Nickel (0.7 g) and aqueous ammonium (3 mL). The reaction was stirred under hydrogen balloon at 35° C. for 4 hours. After removing the Raney-Nickel by filtering through celite pad, the filtrate was concentrated to give (6-thiomorpholinopyridin-3-yl)methanamine 8-4 as a light green solid. MS m/z 210.1 (M+1).

후처리

  1. customAfter removing the Raney-Nickel
  2. filtrationby filtering through celite pad
  3. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-811cf79bf8094e26a331ae233b98d09c
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181235B2

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