Lithium Hydroxide → 1-(3-Fluorophenyl)-2-oxo-1,2-dihydropyridine-4-carboxylic acid

HRID 711279노트

반응식

HRID 711279 반응식
[F:1][C:2]1[CH:3]=[C:4]([N:8]2[CH:13]=[CH:12][C:11]([C:14]([O:16]C)=[O:15])=[CH:10][C:9]2=[O:18])[CH:5]=[CH:6][CH:7]=1.[Li+].[OH-]>O.CO>[F:1][C:2]1[CH:3]=[C:4]([N:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:16])=[O:15])=[CH:10][C:9]2=[O:18])[CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 3939Lithium HydroxideHCID 68083398HCID 68083398, 화합물

생성물 1

HCID 680798531-(3-Fluorophenyl)-2-oxo-1,2-dihydropyridine-4-carboxylic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

To a solution of methyl 1-(3-fluorophenyl)-2-oxo-1,2-dihydropyridine-4-carboxylate 89-2 (50 mg, 0.202 mmol) in water (0.5 mL) and methanol (0.5 mL) was added LiOH (20 mg, 0.835 mmol). After stirring at room temperature for 30 minutes, the mixture was concentrated with rotavap and the residue extracted with ethyl acetate, which was then evaporated to give crude 1-(3-fluorophenyl)-2-oxo-1,2-dihydropyridine-4-carboxylic acid 89-3.

후처리

  1. concentrationthe mixture was concentrated with rotavap
  2. extractionthe residue extracted with ethyl acetate, which
  3. customwas then evaporated

출처 및 근거

ORD 기록
ord-5e497a2d71234e5a85617351badacf58
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181235B2

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