Formic Acid → Methyl 4-formamido-3-methoxybenzoate

HRID 71135

반응식

HRID 71135 반응식
[CH:1](O)=[O:2].C(OC(=O)C)(=O)C.[NH2:11][C:12]1[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][C:13]=1[O:22][CH3:23]>C1COCC1>[CH:1]([NH:11][C:12]1[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][C:13]=1[O:22][CH3:23])=[O:2]

참가 물질

5

반응물 3

HCID 284Formic AcidHCID 7918Acetic AnhydrideHCID 602411Methyl 4-amino-3-methoxybenzoate

생성물 1

HCID 23085082Methyl 4-formamido-3-methoxybenzoate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To formic acid (75 mL) was added dropwise acetic anhydride (50 mL) at room temperature, and the mixture was stirred at room temperature for 40 min. A mixture of methyl 4-amino-3-methoxybenzoate (25 g) in THF (100 mL) was added dropwise to the reaction mixture, and the mixture was stirred at room temperature for 1 hr. Ice water (700 mL) was added to the reaction mixture, and the precipitated solid was collected by filtration. The solid was washed with water (400 mL) to give the title compound (25.8 g).

후처리

  1. additionwas added dropwise to the reaction mixture
  2. stirringthe mixture was stirred at room temperature for 1 hr
  3. filtrationthe precipitated solid was collected by filtration
  4. washThe solid was washed with water (400 mL)

출처 및 근거

ORD 기록
ord-da5866695f654abbb84dcf84c965f3f0
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822699B2

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