Formic Acid → N-(6-bromo-2-methoxypyridin-3-yl)formamide

HRID 71178노트

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HRID 71178 반응식
[CH:1]([OH:3])=O.C(OC(=O)C)(=O)C.[Br:11][C:12]1[N:17]=[C:16]([O:18][CH3:19])[C:15]([NH2:20])=[CH:14][CH:13]=1>CCCCCC>[Br:11][C:12]1[N:17]=[C:16]([O:18][CH3:19])[C:15]([NH:20][CH:1]=[O:3])=[CH:14][CH:13]=1

참가 물질

5

반응물 3

HCID 284Formic AcidHCID 7918Acetic AnhydrideHCID 105361376-Bromo-2-methoxypyridin-3-amine

생성물 1

HCID 71492501N-(6-bromo-2-methoxypyridin-3-yl)formamide

시약·촉매·용매 1

HCID 8058Hexane용매

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온도
0 °C

실험 절차

To formic acid (12 mL) was added acetic anhydride (12 mL) at 0° C., and the mixture was stirred at 0° C. for 30 min. 6-Bromo-2-methoxypyridin-3-amine (8.8 g) was gradually added to the reaction mixture at 0° C. over 10 min, and the mixture was stirred at 0° C. for 30 min. IPE (50 mL) and hexane (50 mL) were added to the reaction mixture, and the mixture was stirred at room temperature for 30 min. The obtained solid was collected by filtration to give the title compound (8.1 g).

후처리

  1. stirringthe mixture was stirred at 0° C. for 30 min
  2. stirringthe mixture was stirred at room temperature for 30 min
  3. filtrationThe obtained solid was collected by filtration

출처 및 근거

ORD 기록
ord-fbf033e887504119a6ae793a850510ce
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822699B2

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