Ammonia → 2-Bromo-4,6-dinitroaniline

HRID 712155

반응식

HRID 712155 반응식
O.[N+:2]([C:5]1[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[CH:9]=[CH:8][C:6]=1[NH2:7])([O-:4])=[O:3].[Br:15]Br.N>C(O)(=O)C>[Br:15][C:8]1[CH:9]=[C:10]([N+:12]([O-:14])=[O:13])[CH:11]=[C:5]([N+:2]([O-:4])=[O:3])[C:6]=1[NH2:7]

참가 물질

6

반응물 4

HCID 222AmmoniaHCID 962WaterHCID 73212,4-DinitroanilineHCID 24408Bromine

생성물 1

HCID 157522-Bromo-4,6-dinitroaniline수율 84%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a stirred mixture of water (3.75 L) and acetic acid (375 mL) at rt was added 2,4-dinitroaniline (500 g, 2.73 mol) followed by dropwise addition of bromine (210 mL, 4.09 mol) over 30 min. The reaction mixture was stirred at rt for 15 min then heated to 100° C. for 2 h. The reaction mixture was then cooled to rt poured onto ice-cold water (5-6 L) and basified (pH 8-10) with aqueous ammonia. The solid thus obtained was filtered, washed with cold water and dried under vacuum. The resulting solid was washed with n-pentane to give the desired product (600 g, 84%).

후처리

  1. temperaturethen heated to 100° C. for 2 h
  2. temperatureThe reaction mixture was then cooled to rt
  3. additionpoured onto ice-cold water (5-6 L)
  4. customThe solid thus obtained
  5. filtrationwas filtered
  6. washwashed with cold water
  7. customdried under vacuum
  8. washThe resulting solid was washed with n-pentane

출처 및 근거

ORD 기록
ord-0bbc4b2c48de4f10b61d6400c7c470a2
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181234B2

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