Hydrochloric Acid → Ethyl 4-hydroxypiperidine-4-carboxylate

HRID 712250노트

반응식

[OH:1][C:2]1([C:8]([OH:10])=[O:9])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.Cl.[CH3:12][CH2:13]O>>[OH:1][C:2]1([C:8]([O:10][CH2:12][CH3:13])=[O:9])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 44371984-hydroxypiperidine-4-carboxylic Acid

생성물 1

HCID 22717992Ethyl 4-hydroxypiperidine-4-carboxylate

반응 조건

온도: 80 °C

실험 절차

To a solution of 4-hydroxypiperidine-4-carboxylic acid (1.20 g, 8.26 mmol) in EtOH (30 ml) was added conc. HCl (5 ml) at rt and the mixture heated up to 80° C. for 2-3 h. After completion (by TLC), solvent was evaporated under reduced pressure to obtain the desired product (1.20 g, crude) which was carried forward for next step without further purification. 1H NMR (D2O): δ 4.20 (q, J=7.20 Hz, 2H), 3.28 (M, 4H), 2.22 (m, 2H), 1.91 (m, 2H), and 1.22 (t, J=7.20 Hz, 3H).

후처리

customAfter completion (by TLC), solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록: ord-be55e4bfe4414e40959400e0b8e12611
출처 데이터셋: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09181234B2

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