Water → HCID 131733986, 화합물

HRID 712353노트

반응식

HRID 712353 반응식
Br.[C:2]([S:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][CH:8]=1)(=[NH:4])[NH2:3].[C:16]([O-])(=O)[CH3:17].[NH4+].C([N:23]=[C:24]=[O:25])C.O>CN(C=O)C>[CH2:16]([N:13]([CH2:10][CH3:11])[C:24]([NH2:23])=[O:25])[CH3:17].[N+:13]([C:10]1[CH:11]=[CH:12][C:7]([CH2:6][S:5][C:2](=[NH:3])[NH2:4])=[CH:8][CH:9]=1)([O-:15])=[O:14]

참가 물질

6

반응물 4

HCID 962WaterHCID 8022Ethyl isocyanateHCID 116350Pseudourea, 2-(p-nitrobenzyl)-2-thio-, monohydrobromideHCID 517165Ammonium Acetate

생성물 1

HCID 131733986HCID 131733986, 화합물수율 41%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 4-nitrobenzyl carbamimidothioate hydrobromide (2.5 g, 8.55 mmol) in DMF (10 mL) was added aqueous buffer solution of ammonium acetate (pH ˜7, 4.0 mL) followed by addition of ethyl isocyanate (10 mL. 85.57 mmol) at rt and the mixture stirred at rt for 48 h. After completion of reaction (by TLC), water (10 mL) was added and a white precipitate formed. The reaction mixture was filtered and solid was washed with water to obtain the desired product as white solid (1.40 g, 41%). MS: 354.18 [M+H]+

후처리

  1. additionwas added
  2. customa white precipitate formed
  3. filtrationThe reaction mixture was filtered
  4. washsolid was washed with water

출처 및 근거

ORD 기록
ord-2a107e64ce68453ea23c0c90efdfd565
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181234B2

반응 노트

불러오는 중…