Ethanol → tert-Butyl octahydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate
반응식
[N:1]1([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[C:5]2=[CH:6][N:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[CH:2]1.CCO>O=[Pt]=O.CC(O)=O>[N:1]1([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH:5]2[CH2:6][NH:7][CH2:8][CH2:9][CH:4]2[CH2:3][CH2:2]1참가 물질
5
실험 절차
A mixture of tert-butyl 1H-pyrrolo[2,3-c]pyridine-1-carboxylate (1.85 g) and a catalytic amount of PtO2 in the mixture solvent of EtOH (10 mL) and AcOH (10 mL) was heated overnight under H2 (2.0 MPa). The reaction mixture was filtered, and the filtrate was concentrated in vacuo. The residue was chromatographed with a silica gel column (eluting agent: 10:1 (v/v) CH2Cl2/MeOH) to afford the product as viscous liquid (2.18 g, 100.00%).
후처리
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate was concentrated in vacuo
- customThe residue was chromatographed with a silica gel column (eluting agent: 10:1 (v/v) CH2Cl2/MeOH)
출처 및 근거
- ORD 기록
- ord-9f3a1e671cc6476f842471b6ab1c6637
- 출처 데이터셋
- uspto-grants-2015_11
- 특허 번호
- US09181277B2
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