1-((Tert-butoxy)carbonyl)-4,4-difluoropiperidine-2-carboxylic acid → Tert-butyl 4,4-difluoro-2-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)piperidine-1-carboxylate

HRID 712827

반응식

HRID 712827 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]([F:15])([F:14])[CH2:10][CH:9]1[C:16]([OH:18])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.[NH2:20][C:21]1([C:24]2[CH:33]=[CH:32][C:27]([C:28]([O:30][CH3:31])=[O:29])=[CH:26][CH:25]=2)[CH2:23][CH2:22]1>>[F:15][C:11]1([F:14])[CH2:12][CH2:13][N:8]([C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])[CH:9]([C:16](=[O:18])[NH:20][C:21]2([C:24]3[CH:33]=[CH:32][C:27]([C:28]([O:30][CH3:31])=[O:29])=[CH:26][CH:25]=3)[CH2:23][CH2:22]2)[CH2:10]1

참가 물질

3

반응물 2

HCID 101069001-((Tert-butoxy)carbonyl)-4,4-difluoropiperidine-2-carboxylic acidHCID 66824369Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride

생성물 1

HCID 117966874Tert-butyl 4,4-difluoro-2-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)piperidine-1-carboxylate수율 69.4%

실험 절차

The title compound (D68) (688 mg) was prepared according to the general procedure for amides preparation (Method C) starting from 1-(tert-butoxycarbonyl)-4,4-difluoropiperidine-2-carboxylic acid (600 mg; described in WO2010148197) and methyl 4-(1-aminocyclopropyl)benzoate hydrochloride (566.5 mg). Reaction time: 5 hrs

후처리

  1. customReaction time
  2. custom5 hrs

출처 및 근거

ORD 기록
ord-f42d9d81c8d142c3b6715110002965ae
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181279B2

연결된 노트

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