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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 712827생성일: 2026년 10월 26일

1-((Tert-butoxy)carbonyl)-4,4-difluoropiperidine-2-carboxylic acid → Tert-butyl 4,4-difluoro-2-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)piperidine-1-carboxylate

https://huagongshe.com/reaction/712827

반응식

참여 물질

역할이름HCID투입량
반응물1-((Tert-butoxy)carbonyl)-4,4-difluoropiperidine-2-carboxylic acidHCID 10106900—
반응물Methyl 4-(1-aminocyclopropyl)benzoate hydrochlorideHCID 66824369—
생성물Tert-butyl 4,4-difluoro-2-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)piperidine-1-carboxylateHCID 11796687469.4%

반응 단계

The title compound (D68) (688 mg) was prepared according to the general procedure for amides preparation (Method C) starting from 1-(tert-butoxycarbonyl)-4,4-difluoropiperidine-2-carboxylic acid (600 mg; described in WO2010148197) and methyl 4-(1-aminocyclopropyl)benzoate hydrochloride (566.5 mg). Reaction time: 5 hrs

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09181279B2
출처 데이터셋uspto-grants-2015_11
ORD IDord-f42d9d81c8d142c3b6715110002965ae
출처 메모uspto-grants-2015_11