Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Carbonate → 3-(Trifluoromethyl)benzyl 4-hydroxy-1-(3-(trifluoromethyl)benzyl)pyrrolidine-2-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 1-(Bromomethyl)-3-(trifluoromethyl)benzene | HCID 123061 | — |
| 반응물 | Cis-4-Hydroxy-D-Proline | HCID 440014 | — |
| 생성물 | 3-(Trifluoromethyl)benzyl 4-hydroxy-1-(3-(trifluoromethyl)benzyl)pyrrolidine-2-carboxylate | HCID 90353857 | — |
반응 단계
The title compound (D81) (1.02 g) was prepared according to the general procedure for substituted benzyl amines preparation starting from cis-4-Hydroxy-D-proline (4.0 g; available from Aldrich#H5877) and 3-(Trifluoromethyl)benzyl bromide (9.37 ml). (Na2CO3: 2.5 eq; Reaction time: 24 hrs; 60° C.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09181279B2 |
| 출처 데이터셋 | uspto-grants-2015_11 |
| ORD ID | ord-47c1ce7c4c6d4ae78b39c83b454689b6 |
| 출처 메모 | uspto-grants-2015_11 |