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Acetic Acid → 1-(10,10-Dimethyl-11-oxa-3,8-diazaspiro[5.5]undecan-3-yl)-2,2,2-trifluoro-ethanone acetic acid salt

HRID 712951
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HRID 712951 반응식
[C:1]([OH:4])(=[O:3])[CH3:2].C([N:12]1[CH2:28][C:27]([CH3:30])([CH3:29])[O:26][C:14]2([CH2:19][CH2:18][N:17]([C:20](=[O:25])[C:21]([F:24])([F:23])[F:22])[CH2:16][CH2:15]2)[CH2:13]1)C1C=CC=CC=1.Cl.[H][H]>[OH-].[OH-].[Pd+2].C(O)C>[C:1]([OH:4])(=[O:3])[CH3:2].[CH3:29][C:27]1([CH3:30])[O:26][C:14]2([CH2:19][CH2:18][N:17]([C:20](=[O:25])[C:21]([F:22])([F:23])[F:24])[CH2:16][CH2:15]2)[CH2:13][NH:12][CH2:28]1
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참가 물질

7

반응물 4

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 866724521-(8-Benzyl-10,10-dimethyl-11-oxa-3,8-diazaspiro[5.5]undecan-3-yl)-2,2,2-trifluoro-ethanoneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 866724531-(10,10-Dimethyl-11-oxa-3,8-diazaspiro[5.5]undecan-3-yl)-2,2,2-trifluoro-ethanone acetic acid salt

시약·촉매·용매 2

HCID 9942167
Palladium hydroxide
촉매
HCID 702Ethanol용매

실험 절차

A mixture of acetic acid (100 μL, 1.76 mmol), Pd(OH)2 (11 mg, 0.02 mmol), 1-(8-benzyl-10,10-dimethyl-11-oxa-3,8-diazaspiro[5.5]undecan-3-yl)-2,2,2-trifluoro-ethanone (80 mg, 0.22 mmol), HCl (108 μL of 4 M in dioxane, 0.43 mmol) and ethanol (2 mL) was treated to an atmosphere of hydrogen at 85 psi for 3 days. The reaction mixture was filtered and the catalyst was washed with methanol, then concentrated in vacuo to give 1-(10,10-dimethyl-11-oxa-3,8-diazaspiro[5.5]undecan-3-yl)-2,2,2-trifluoro-ethanone acetic acid salt as a yellow solid. ESI-MS m/z calc. 280.1. found 281.5 (M+1)+; Retention time: 0.91 minutes (3 min run).

후처리

  1. filtrationThe reaction mixture was filtered
  2. washthe catalyst was washed with methanol
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-d4910923c45c400ab8eafc6985b069c7
출처 데이터셋
uspto-grants-2015_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09181273B2

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