Hydrochloric Acid → Hydrochloric Acid

HRID 713178노트

반응식

HRID 713178 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([F:23])=[C:6]([CH:22]=1)[C:7]([CH:9]1[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]1)=[O:8].[ClH:24]>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([F:23])=[C:6]([C:7]([CH:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)=[O:8])[CH:22]=1.[ClH:24]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 49761188tert-Butyl 4-(5-chloro-2-fluorobenzoyl)piperidine-1-carboxylate

생성물 2

HCID 313Hydrochloric Acid수율 475%HCID 49761187(5-Chloro-2-fluorophenyl)(piperidin-4-yl)methanone

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A solution of tert-butyl 4-(5-chloro-2-fluorobenzoyl)piperidine-1-carboxylate (287.9 mg, 0.843 mmol) in dioxane (2.41 mL) was treated with HCl (2.11 mL, 8.43 mmol) at rt and the resulting reaction mixture was stirred overnight. The reaction mixture was diluted with hexanes and filtered by suction to afford (5-chloro-2-fluorophenyl)(piperidin-4-yl)methanone as its HCl salt (146 mg, 62.3%) as a yellow solid. ESI-MS m/z [M+H]+242.20.

후처리

  1. customthe resulting reaction mixture
  2. filtrationfiltered by suction

출처 및 근거

ORD 기록
ord-9d49f41d15444870bf1ce1c65a16e3fa
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181249B2

반응 노트

불러오는 중…