Sodium borohydride → HCID 49760120, 화합물

HRID 713183노트

반응식

HRID 713183 반응식
[F:1][C:2]1[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:3]=1[C:4]([CH:6]1[CH2:11][CH2:10][N:9]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:8][CH2:7]1)=[O:5].[BH4-].[Na+]>CO>[F:1][C:2]1[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:3]=1[CH:4]([OH:5])[CH:6]1[CH2:11][CH2:10][N:9]([C:12]([O:14][C:15]([CH3:17])([CH3:16])[CH3:18])=[O:13])[CH2:8][CH2:7]1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 49760095tert-Butyl 4-(2,4-difluorobenzoyl)piperidine-1-carboxylate

생성물 1

HCID 49760120HCID 49760120, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a 0° C. solution of tert-butyl 4-(2,4-difluorobenzoyl)piperidine-1-carboxylate (1.28 g, 3.93 mmol) in MeOH (15.7 mL) was added NaBH4 (0.372 g, 9.84 mmol). The ice bath was removed and the reaction mixture stirred for 2 h at room temperature then was quenched with saturated aqueous NH4Cl. The organic layer was extracted with EtOAc, washed with H2O and dried over MgSO4. The solvent was removed under reduced pressure gave tert-butyl 4-((2,4-difluorophenyl)(hydroxy)methyl)piperidine-1-carboxylate as a white hygroscopic solid.

후처리

  1. customThe ice bath was removed
  2. customthen was quenched with saturated aqueous NH4Cl
  3. extractionThe organic layer was extracted with EtOAc
  4. washwashed with H2O
  5. dry with materialdried over MgSO4
  6. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-982a4f4aff0b4771b17ddf158a892c31
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181249B2

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