Ethyl cyanoacetate → Ethyl 1-cyanocyclopropanecarboxylate
반응식
[C:1]([CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5])#[N:2].Br[CH2:10][CH2:11]Br.C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[C:1]([C:3]1([C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH2:11][CH2:10]1)#[N:2]참가 물질
5
반응 조건
- 온도
- 80 °C
실험 절차
Ethyl 2-cyanoacetate (0.85 g, 7.5 mmol, 1 equiv), 1,2-dibromoethane (1.3 mL, 15 mmol, 2 equiv) and K2CO3 (3.18 g, 22.5 mmol, 3 equiv) was dissolved in acetone (6 mL), and the mixture was stirred for 16 h at 80° C. The reaction mixture was filtered, concentrated to give the crude product as a yellow oil (1.84 g, 100%). 1H NMR (400 MHz, DMSO-d6) δ: 4.18 (t, 2H), 1.75 (t, 2H), 1.60 (m, 2H), 1.20 (t, 3H).
후처리
- filtrationThe reaction mixture was filtered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-0ff2867da20e4f09bc6d2dc7550181bb
- 출처 데이터셋
- uspto-grants-2015_11
- 특허 번호
- US09186367B2
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